In recent years, a growing body of research has pointed to NAD⁺ (nicotinamide adenine dinucleotide) as a key molecule in the ageing process. While it’s not quite a “fountain of youth,” a notable study from Harvard has sparked hope that we may one day meaningfully slow — or even partially reverse — some cellular signs of ageing. Now, Toronto clinics are beginning to make NAD+ therapy available to Canadians.
What the Harvard research actually shows
Researchers led by Harvard’s David Sinclair and colleagues found that boosting NAD⁺ levels in animal models could reverse vascular ageing and improve muscle function. Their work suggests that NAD⁺ supports DNA repair, mitochondrial function, and healthy cell signalling — mechanisms that deteriorate over time.
More recently (2025), Harvard researchers also published work linking NAD⁺ transporters, such as SLC25A51, to age-related dysfunction in insulin-secreting pancreatic cells, demonstrating that manipulating NAD⁺ pathways might also influence metabolic health and reduce cell senescence. The implication: the benefits of NAD⁺ may extend beyond one tissue or system.
Still, a caution: while these results in mice and cells are promising, robust human trials remain limited. Some experts warn the current evidence for NAD⁺ infusions is preliminary and does not yet fully confirm all claimed anti-ageing benefits. Always consult a licensed medical professional before pursuing such therapies.
Why NAD⁺ declines as we age
As we get older, several factors contribute to falling NAD⁺ levels:
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Increased expression of CD38, an enzyme that degrades NAD⁺.
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Greater DNA damage and cellular stress, which draw on NAD⁺ reserves in repair pathways.
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Mitochondrial dysfunction, reducing the efficiency of NAD⁺ recycling and generation.
By restoring NAD⁺ levels — for example, via precursors like NMN (nicotinamide mononucleotide) or NAD⁺ infusions — researchers hope to reinvigorate repair pathways and slow cellular wear and tear.
You can read more background on NMN via Wikipedia: Nicotinamide mononucleotide (NMN)
NAD⁺ therapy arrives in Toronto — what to know
In the Greater Toronto Area, several wellness and functional medicine clinics now offer NAD⁺ infusion or drip protocols. Some key considerations:
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Therapy is usually intravenous (IV) infusion, delivering NAD⁺ directly into the bloodstream.
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Clinics may also combine NAD⁺ with vitamins, amino acids, antioxidants, or other nutrients to support cellular recovery.
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Costs can be high, and there is variability in protocols (dosage, frequency, duration).
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Safety profiles are still being evaluated; potential side effects include fatigue, flushing, or mild GI discomfort.
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Because regulation in Canada is still evolving, ensure any provider is licensed and follows standard medical and safety protocols.
At MMediSpa Toronto, we are actively monitoring developments in NAD⁺ therapy. Our goal is always to integrate treatments supported by strong science, in a safe, fully informed manner.
Practical tips if you’re considering NAD⁺ therapy in Toronto
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Medical screening & baseline testing
Before treatment, a clinic should assess your health status (labs, kidney/liver function, metabolic profile) and discuss contraindications.
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Start with conservative protocols
Begin with lower doses or intermittent schedules; allow your body to adjust and observe responses.
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Lifestyle support matters
Exercise, sleep, and a nutrient-rich diet support NAD⁺ naturally. For instance, calorie restriction and mitochondrial support can preserve NAD⁺.
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Monitor outcome metrics
Track energy levels, cognitive clarity, recovery time, and lab biomarkers over time.
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Stay informed on emerging trials
As human clinical research expands, optimal regimens and biomarkers will become clearer.
If you’re curious about how NAD⁺ therapy might complement treatments we already offer at MMediSpa, get in touch — we can review whether you might be a suitable candidate.
Takeaway
The Harvard-led research on NAD⁺ has ignited hope for a future in which ageing is less of a one-way march and more of a mitigable process. While much of the promise remains to be validated in humans, the appearance of NAD⁺ therapy in Toronto marks a new frontier in anti-ageing wellness. With proper medical oversight, it may one day become an integral tool in our longevity toolkit.
To stay updated on related science news, visit the Harvard Medical School site or check NIH/NCBI resources — for instance, the “Rewinding the Clock” research summary from Harvard.